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Gene Fitness

Have you ever wondered why most Olympic sprint winners are Jamaicans? Why the worlds best marathon runners are from Africa? Do you want to know if you are really built for the sport you love? The answer may lie in your genetics. Recent research has confirmed that our ability to perform strenous physical activity is dependent on a number of our genes. Inheritance of favourable genetic components is more commonly observed in athletes or fitness professionals depending on the type of exercise or sports activity they perform. Genes have a powerful role in determining your sports performance and fitness level. Genetic make up also determines the body’s endurance level towards an exercise activity, and the duration and rate at which a positive outcome can be achieved in improving your fitness. Test your DNA at home with GeneXpert, We will assist you to reach your Fitness level

Hence, this section of your report helps you in deciding a fitness regimen that suits you best and benefits you the most!

“Genetics plays a part in who
we are and how we perform!”

Aerobic Capacity

Aerobic capacity (VO2 max) is defined as the maximum capacity of our body to transport and use oxygen during exercise. During exercise oxygen is used to break down fuel stores for energy production and its demand increases. A good aerobic capacity is essential for a comfortable workout. Various genes regulate our aerobic capacity and hence they have a vital role in deciding our fitness level. We have analysed genes that are involved in cellular oxygen supply & utilization like VEGFA, ADRB2, PPARA, GABPB1.

Anaerobic capacity

Anaerobic capacity is the total amount of energy obtainable from the anaerobic energy systems. The better able your anaerobic energy systems are at utilising energy and recovering, the higher the intensity you are able to maintain. By increasing anaerobic capacity you will be able to buffer more lactate at a faster rate, produce and use more anaerobic enzymes and continue turning body fuels into useable energy for immediate access. We have analysed genes that have shown to be associated with anaerobic threshold like PPARGC1A, PPACD.

Endurance

Endurance is body’s capacity to utilize oxygen for energy production, and sustain it for a prolonged duration during a physical activity. A high endurance capacity indicates that an individual can take up mild to moderate intensity activity for a prolonged duration, with minimal discomforts like breathlessness and fatigue. We have analyzed genes that have a role in determining the endurance aspects such as type of fuel used by the cell for energy production, percentage distribution of muscle fibers (slow twitch and fast twitch) and the adaptability of the blood vessel to carry more oxygen. This includes almost 10 genes involved in it like ACTN 3, PPARA, GABPB1, PPARGC1A, PPARD, VEGFA, ADRB2, MCTI, PPARA, ACE.

Power

Power measures the rapid burst of energy observed during the high intensity activities of shorter duration. Type II or fast twitch muscle fibers allow us to perform rapid, high intensity exercises. The ability of blood vessels to constrict and make oxygen utilization more efficient is also important for power. We have analysed genes that determine the percentage distribution of muscle fibers (slow twitch and fast twitch) and their ability to exert maximal power over a short period of time. Genes ACTN3, ACE, MTC1, NOS3 evaluate Power based performance.

Flexibility

Flexibility is the ability of your joints and muscles to move freely (Range of motion). Ligaments & tendons are natural lubricants that are essential for flexibility. Flexibility is important in fitness because it allows for better performance when playing sports or exercising. It also adds to your level of comfort in day-to-day activities such as bending, walking and lifting. Flexibility is attributed to the protein collagen that surrounds the cells. We have analyzed the gene that could potentially influence your flexibility and performance by influencing composition of ligaments and tendons like COL5A1.

Muscle fatigue & Threshold

Do you normally feel excessively fatigued after exercise? If yes, the answer to this may be in the expression of certain genes in your body. Lactate is the preferred source of fuel for energy production in the exercising muscle when there is a lack of oxygen (anaerobic metabolism). When muscles use up energy during physical activity, there are chances for lactate build-up, which is a major cause of muscle fatigue. Apart from this, exercise-induced rise in inflammation and sub-optimal flexibility are other contributing factors for muscle fatigue. Your ability to resist muscle fatigue is the deciding factor of how long you can exercise and also the intensity of exercise that is well suited for your body. The gene TNFA, COL5M determines muscle fatigue while MCT1 shows ate threshold.

Muscle injury

Sportsmen and runners who place stress on the Achilles tendon have the greatest likelihood of muscle injury and tendinopathy. The Achilles tendon connects your calf muscles to your heel bone. Tendinopathy describes either the inflammation or tiny tears to the tendon. Individuals with certain genotypes have certain are more prone to injury than others and such individuals are at increased risk of tendinopathy and other muscle injury. The genes MCT1, MMP3 & COL5A1 depict increased predisposition to muscle injury.

Injury Repair

One of the greater yet lesser-known advantages of regular exercise is that it improves immunity. It increases our resistance to fight infection, speeds up recovery from external trauma and even reduces the effect of autoimmune diseases. An inflammation is observed in response to exercise and it naturally subsides once we adapt to the physical strain or exercise. The rate at which exercise-induced inflammation subsides or resumes basal level determines the extent of recovery and the duration of rest periods required in between exercises. We have analyzed genes that determine the efficacy of muscle repair after an exercise-induced injury. The need for mild, moduate or intensive rehabilitation protocol in case of injuries/surgies are determined by the genes MMP3, 1L6.

Ex 7 fat Ion

Exercise can positively regulate bodily functions and decrease fat levels. Regular exercise renders weight control through improved metabolism and oxidation of fatty acids. Oxidized fatty acids in addition to glucose can be used as a fuel source for the body during exercise. Regular exercise is a healthy way for fat loss and weight control. How efficiently people respond to exercise in terms of fat oxidation is dependent on their genes. The influence of the carbohydrate & fat metabolism impacts weight response to exercise as assessed by the presence or absence of the genes LIPC, IMSIG 2.

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